Article

<i>ST3GAL3</i> loss-of-function disrupts synaptic integrity and excitatory/inhibitory cortical dynamics

2026-06-25

Abstract excerpt

This study examined the role of ST3GAL3 as a regulator of excitatory/inhibitory (E/I) synaptic homeostasis using a human iPSC-based model. Neurodevelopmental disorders (NDDs) are increasingly linked to disruptions in the E/I balance, yet the molecular determinants remain poorly defined. ST3GAL3, a sialyltransferase associated with both rare monogenic disorders, including intellectual disability and infantile epile...

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Literature Corpus work: c856c220-4a70-535d-858d-e0b00a56f3cd
DOI: 10.64898/2026.06.21.733355

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