Article

L-type voltage-gated calcium channel regulation of <i>in vitro</i> human cortical neuronal networks

2018-11-07

Abstract excerpt

The combination of in vitro multi-electrode arrays (MEAs) and the neuronal differentiation of stem cells offers the capability to study human neuronal networks from patient or engineered human cell lines. Here, we use MEA-based assays to probe synaptic function and network interactions of hiPSC-derived neurons. Neuronal network behaviour first emerges at approximately 30 days of culture and is driven by glutamate...

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Literature Corpus work: 72d086c8-5950-5ad7-96ad-204a39fae8c3
DOI: 10.1101/464677

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