Article

Expression profile of the ADHD risk gene <i>ADGRL3</i> during human neurodevelopment and the effects of genetic variation

2025-01-29

Abstract excerpt

Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders, affecting ∼5.3 % children, with symptoms including hyperactivity, inattention and impulsivity. Moreover, ADHD persists into adulthood in ∼50 % cases, significantly affecting quality of life. Currently, the complex aetiology of ADHD remains unclear, although it has been shown that it is a highly heritable disorde...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eb1ad928-f41b-5d8e-993f-3ef9e47f5606
DOI: 10.1101/2025.01.29.635411

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Expression profile of the ADHD risk gene <i>ADGRL3</i> during human neurodevelopment and the effects of genetic variationDOI 10.1101/2025.01.29.635411Read

Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3.Semantic proximity Read

Meta-analysis and systematic review of ADGRL3 (LPHN3) polymorphisms in ADHD susceptibility.Semantic proximity Read

Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors.Semantic proximity Read

An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility.Semantic proximity Read

hiPSC-derived cortical neurons from ADHD individuals reveal dysregulated glutamatergic developmentSemantic proximity Read

ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIPSemantic proximity Read

Dances with black widow spiders: dysregulation of glutamate signalling enters centre stage in ADHD.Semantic proximity Read

Integrative multi-omics data from early development to identify the genes and cell types underlying attention-deficit/hyperactivity disorder.Semantic proximity Read

<i> <scp>ADGRL</scp> 3 ( <scp>LPHN</scp> 3) </i> variants are associated with a refined phenotype of <scp>ADHD</scp> in the <scp>MTA</scp> studySemantic proximity Read

Rare genetic variants confer a high risk of ADHD and implicate neuronal biology.Semantic proximity Read

Adhesion G protein-coupled receptor L3 gene variants: Statistically significant association observed in the male Indo-caucasoid Attention deficit hyperactivity disorder probands.Semantic proximity Read

ADGRL3 rs6551665 as a Common Vulnerability Factor Underlying Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.Semantic proximity Read