Article

“Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression”

2019-10-13

Abstract excerpt

Base excision repair (BER) initiated by alkyladenine DNA glycosylase (AAG; aka MPG) is essential for removal of aberrantly methylated DNA bases. Genome instability and accumulation of aberrant bases accompany multiple diseases including cancer and neurological disorders. While BER is well studied on naked DNA, it remains unclear how BER efficiently operates on chromatin. Here we show that AAG binds to chromatin an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2ac211b2-94a1-5a34-9b08-9a0fe1859347
DOI: 10.1101/802983

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

“Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression”DOI 10.1101/802983Read

The Link Between Human Alkyladenine DNA Glycosylase and Cancer DevelopmentSemantic proximity Read

A DNA repair-independent role for alkyladenine DNA glycosylase in alkylation-induced unfolded protein responseSemantic proximity Read

Genome maintenance and transcription integrity in aging and diseaseSemantic proximity Read

Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.Semantic proximity Read

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cellsSemantic proximity Read

Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repairSemantic proximity Read

XPG and XPF endonucleases trigger chromatin looping and DNA demethylation for accurate expression of activated genes.Semantic proximity Read

AP endonuclease 1 prevents the extension of a T/G mismatch by DNA polymerase β to prevent mutations in CpGs during base excision repair.Semantic proximity Read

DNA mismatch repair preferentially safeguards actively transcribed genes.Semantic proximity Read

The alternative lengthening of telomeres mechanism jeopardizes telomere integrity if not properly restrictedSemantic proximity Read

Apurinic/apyrimidinic endodeoxyribonuclease 2 ( <i>APEX2</i> /APE2) is required for efficient expression of <i>TERT</i> in human embryonic stem cellsSemantic proximity Read

The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents.Semantic proximity Read