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Genome maintenance and transcription integrity in aging and disease

1 Jan 2013

Abstract excerpt

DNA damage contributes to cancer development and aging. Congenital syndromes that affect DNA repair processes are characterized by cancer susceptibility, developmental defects, and accelerated aging (Schumacher et al., 2008). DNA damage interferes with DNA metabolism by blocking replication and transcription. DNA polymerase blockage leads to replication arrest and can gives rise to genome instability....

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PMID: 23443494
DOI: 10.3389/fgene.2013.00019

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