Article

Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair

2016-08-17

Abstract excerpt

Reactive oxygen species (ROS) have emerged as important cellular signaling agents for survival. Herein, we demonstrate that ROS-mediated oxidation of DNA to yield 8-oxo-7,8-dihydroguanine (OG) in gene promoters is a signaling agent for gene activation. Enhanced gene expression occurs when OG is formed in guanine-rich, potential G-quadruplex sequences (PQS) in promoter coding strands to initiate base excision repai...

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Identifiers and source

Literature Corpus work: 64892b70-a46d-539b-908e-fdea6513e81e
DOI: 10.1101/069955

Open publication

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