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Article

The elongator complex interacts with PCNA and modulates transcriptional silencing and sensitivity to DNA damage agents.

PLoS genetics - 1 Oct 2009

Li Qing, Fazly A M, Zhou Hui, Huang Shengbing, Zhang Zhiguo, Stillman Bruce

Abstract excerpt

Histone chaperones CAF-1 and Asf1 function to deposit newly synthesized histones onto replicating DNA to promote nucleosome formation in a proliferating cell nuclear antigen (PCNA) dependent process. The DNA replication- or DNA repair-coupled nucleosome assembly pathways are important for maintenance of transcriptional gene silencing and genome stability. However, how these pathways are regulated is not well...

Topics

DNA Damage
Gene Expression Regulation, Fungal
Gene Silencing
Genomic Instability
Histone Acetyltransferases
Histones
Mutation
Proliferating Cell Nuclear Antigen
Protein Binding
S Phase
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae Proteins

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 19834596
DOI: 10.1371/journal.pgen.1000684
PMCID: PMC2757915

Genes

PCNA
ELP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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