Article

CDK8 and CDK19 kinases have non-redundant oncogenic functions in hepatocellular carcinoma

2019-10-01

Abstract excerpt

Hepatocellular carcinoma (HCC) is a common cancer with high mortality. The limited therapeutic options for advanced disease include treatment with Sorafenib, a multi-kinase inhibitor whose targets include the Mediator kinase CDK8. Since CDK8 has reported oncogenic activity in Wnt-dependent colorectal cancer, we investigated whether it is also involved in HCC. We find that CDK8 and its paralogue CDK19 are significa...

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Literature Corpus work: 2abfde29-05a8-5d34-a6e0-943da6647058
DOI: 10.1101/789586

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