Article

Simvastatin attenuates disease phenotypes in human induced pluripotent stem cell models of familial Parkinson's disease through RhoA inhibition

2026-08-31

Abstract excerpt

<h4>Background: </h4> Statins have gained increasing interest for their potential therapeutic effect in Parkinson's disease (PD). Beyond their cholesterol-lowering effect, statins decrease synthesis of isoprenoids, which is believed to account for their pleiotropic effects. Isoprenylation is important for proper membrane localization and function of the Rho GTPases, including RhoA. RhoA signalling has emerged as a...

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Literature Corpus work: df0b7ba8-887e-5087-af4b-e32d0f698f1c
DOI: 10.64898/2026.08.26.747232

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