Article

Mutations in PLA2G6 impair ER–mitochondria contacts and ceramide homeostasis via GRP75 in Parkinson’s disease

2025-08-22

Abstract excerpt

<title>Abstract</title> <p>Background Loss-of-function mutations in <italic>PLA2G6</italic> cause mitochondrial abnormalities that contribute to Parkinson’s disease (PD), yet the precise mechanisms remain elusive. Methods We combined genetic, cellular, and pharmacological approaches to investigate the role of PLA2G6 in Parkinson’s disease. The <italic>PLA2G6</italic> D331Y knock-in mouse model, PLA2G6 knockout ce...

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Literature Corpus work: 549298e4-a673-5d8a-bd45-d26fd2c96e94
DOI: 10.21203/rs.3.rs-7426255/v1

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