Back to search

Article

The natural flavonoid dihydromyricetin targets senescent cells <i>via</i> PRDX2 and alleviates age-related diseases

2025-12-25

Abstract excerpt

Aging is a preeminent risk factor for chronic diseases, with cellular senescence as one of the major hallmarks and an effective target to delay, prevent or alleviate age-related disorders. Here we report in vitro screening outputs from a natural medicinal agent (NMA) library, wherein dihydromyricetin (DMY), a natural flavonoid, showed senotherapeutic potential. DMY protected senescent fibroblasts from further DNA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
9b8da16c-9f87-5a35-9f05-a61b84e6786b
DOI
10.64898/2025.12.25.696450
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The natural flavonoid dihydromyricetin targets senescent cells <i>via</i> PRDX2 and alleviates age-related diseasesDOI 10.64898/2025.12.25.696450
Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelinesSemantic proximity
Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseasesSemantic proximity
New Trends in Aging Drug DiscoverySemantic proximity
Development of novel flavonoid senolytics through phenotypic drug screening and drug designSemantic proximity
The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stressSemantic proximity
Flavonoids—Natural Gifts to Promote Health and LongevitySemantic proximity
Procyanidin C1 is a natural agent with senolytic activity against aging and age-related diseasesSemantic proximity
A second generation of senotherapies: the development of targeted senolytics, senoblockers and senoreversers for healthy ageingSemantic proximity
The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stressSemantic proximity
Senotherapeutics: Targeting senescent cells for the main age-related diseasesSemantic proximity
Targeting the hallmarks of aging: mechanisms and therapeutic opportunitiesSemantic proximity
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in miceSemantic proximity
Select a neighboring publication to make it the new centre.