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Article

p53 induces transcriptional and translational programs to suppress cell proliferation and growth

17 Apr 2013

Abstract excerpt

BACKGROUND: Cell growth and proliferation are tightly connected to ensure that appropriately sized daughter cells are generated following mitosis. Energy stress blocks cell growth and proliferation, a critical response for survival under extreme conditions. Excessive oncogenic stress leads to p53 activation and the induction of senescence, an irreversible state of cell-cycle arrest and a critical component in the...

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PMID: 23594524
DOI: 10.1186/gb-2013-14-4-r32

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