Article
Driver mutations of the adenoma-carcinoma sequence govern the intestinal epithelial global translational capacity.
Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2020
Smit Wouter Laurentius, Spaan Claudia Nanette, Johannes de Boer Ruben, Ramesh Prashanthi, Martins Garcia Tânia, Meijer Bartolomeus Joannes, Vermeulen Jacqueline Ludovicus Maria, Lezzerini Marco, MacInnes Alyson Winfried, Koster Jan, Medema Jan Paul, van den Brink Gijs Robert, Muncan Vanesa, Heijmans Jarom
Abstract excerpt
Deregulated global mRNA translation is an emerging feature of cancer cells. Oncogenic transformation in colorectal cancer (CRC) is driven by mutations in APC, KRAS, SMAD4, and TP53, known as the adenoma-carcinoma sequence (ACS). Here we introduce each of these driver mutations into intestinal organoids to show that they are modulators of global translational capacity in intestinal epithelial cells. Increased...
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