Article
Ribosome biogenesis as a potential therapeutic target in KRAS mutant colorectal cancer.
Nature communications - 27 Dec 2025
Tanaka Yui, Sakahara Mizuho, Yamanaka Hitomi, Natsume Yasuko, Kusama Daisuke, Kumegawa Kohei, Yoshikawa Harunori, Abe Yuich, Okabayashi Koji, Matui Shimpei, Kitagawa Yuko, Koshikawa Naohiko, Osumi Hiroki, Shinozaki Eiji, Nagayama Satoshi, Adachi Jun, Maruyama Reo, Yao Ryoji
Abstract excerpt
Molecular targeted therapies targeting KRAS signaling have significantly improved patient outcomes, but they have not achieved sufficient therapeutic efficacy in colorectal cancer (CRC). Here, we demonstrate that a subset of KRAS-mutant CRC cells transitions to a cellular state characterized by enhanced ribosome biogenesis upon KRAS signaling inhibition. The mitogen-activated protein kinase kinase inhibitor,...
Topics
- Colorectal Neoplasms
- Proto-Oncogene Proteins p21(ras)
- Humans
- Animals
- Ribosomes
- Pyridones
- Mice
- Pyrimidinones
- Cell Line, Tumor
- Mutation