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Macrodomain catalytic activity modulates Chikungunya virus dissemination and transmission potential in <i>Aedes</i> mosquitoes

2025-10-09

Abstract excerpt

Viral macrodomains are promising antiviral targets that counteract host ADP-ribosylation-mediated antiviral responses in mammals. However, their role in dual-host viruses within the mosquito vector remains largely unknown. Here, we investigated the role of the Chikungunya virus (CHIKV) nsP3 macrodomain catalytic activity by mutating the active-site asparagine 24 (N24). N24 mutant viruses rapidly selected for compe...

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Identifiers and source

Literature Corpus work
2a70b08f-a439-54be-a372-c10df5e36f5e
DOI
10.1101/2025.10.09.681498
Open publication

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Macrodomain catalytic activity modulates Chikungunya virus dissemination and transmission potential in <i>Aedes</i> mosquitoesDOI 10.1101/2025.10.09.681498
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