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ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

31 Jan 2017

Abstract excerpt

Significance Viral outbreaks can be sudden and result in devastating social and economic consequences. Chikungunya virus (CHIKV) outbreaks of rash, arthritis, and neurologic disease have occurred in Africa, Asia, Europe, and the Americas. There are no licensed vaccines to prevent or drugs to treat CHIKV infection, and the mechanisms of disease generation are poorly understood. Here, we identify a...

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PMID: 28143925
DOI: 10.1073/pnas.1621485114

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