Article

<i>In silico</i> analysis of the Chikungunya virus and SARS-CoV-2 Macrodomain

2025-10-12

Abstract excerpt

The macrodomain of the Chikungunya virus NSP3 protein (ChikV Mac1) hydrolyzes mono-ADP ribose post-translational modifications on the human host proteins. Mutations in Mac1 reduce ChikV virulence. Thus, ChikV Mac1 is a viral drug target. While no potent ChikV Mac1 inhibitors are available, high-affinity inhibitors were developed for Mac1 in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Here, we rat...

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Literature Corpus work: 7b6e3849-53f4-53b4-ab55-ad4ad5a88832
DOI: 10.1101/2025.10.10.681726

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