Article

An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication

2021-03-31

Abstract excerpt

<h4>ABSTRACT</h4> All coronaviruses (CoVs) contain a macrodomain, also termed Mac1, in non-structural protein 3 (nsp3) which binds and hydrolyzes ADP-ribose covalently attached to proteins. Despite several reports demonstrating that Mac1 is a prominent virulence factor, there is still a limited understanding of its cellular roles during infection. Currently, most of the information regarding the role of CoV Mac1...

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Literature Corpus work: f95b9be0-9862-5084-9c72-c191ec1c1496
DOI: 10.1101/2021.03.30.437796

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