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Article

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential

1 Nov 2020

Abstract excerpt

Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational modification implicated in the creation of an antiviral environment via immune response regulation. This brought them into focus as promising therapeutic targets, albeit the close homology to some of the human macrodomains raised concerns regarding potential cross-reactivity and adverse effects for the host. Here, we...

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PMID: 33202171
DOI: 10.1098/rsob.200237

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