Article
The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases.
Scientific reports - 2 Feb 2017
Eckei Laura, Krieg Sarah, Bütepage Mareike, Lehmann Anne, Gross Annika, Lippok Barbara, Grimm Alexander R, Kümmerer Beate M, Rossetti Giulia, Lüscher Bernhard, Verheugd Patricia
Abstract excerpt
Human pathogenic positive single strand RNA ((+)ssRNA) viruses, including Chikungunya virus, pose severe health problems as for many neither efficient vaccines nor therapeutic strategies exist. To interfere with propagation, viral enzymatic activities are considered potential targets. Here we addressed the function of the viral macrodomains, conserved folds of non-structural proteins of many (+)ssRNA viruses....
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