Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?

23 Apr 2020

Abstract excerpt

Chikungunya virus (CHIKV) is a mosquito-transmitted virus of special concern as it causes Chikungunya fever, characterized by an acute febrile illness, rash, and arthralgia that can progress to chronic and debilitating arthritic symptoms. The effects of climate change on the geographic distribution of the mosquito vector has the potential to expose more of the globe to this virus. No antiviral agents or vaccines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mosquito-borne diseases and control
Share to Plant Virus Research Studies

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 32333884
DOI: 10.1016/j.actatropica.2020.105490

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Is the ADP ribose site of the Chikungunya virus NSP3 Macro domain a target for antiviral approaches?PMID 32333884Read ↗

In silico identification of chikungunya virus replication inhibitor validated using biochemical and cell‐based approachesSemantic proximity Read ↗

ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulenceSemantic proximity Read ↗

Identification and Characterization of Novel Chikungunya Virus Polymerase InhibitorsSemantic proximity Read ↗

Chikungunya virus drug discovery: still a long way to go?Semantic proximity Read ↗

Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational DockingSemantic proximity Read ↗

Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping MachinerySemantic proximity Read ↗

Characterization of the RNA-dependent RNA polymerase from Chikungunya virus and discovery of a novel ligand as a potential drug candidateSemantic proximity Read ↗

The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding PocketSemantic proximity Read ↗

The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases.Semantic proximity Read ↗

Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 MacrodomainSemantic proximity Read ↗

Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice.Semantic proximity Read ↗

Macrodomain catalytic activity modulates Chikungunya virus dissemination and transmission potential in <i>Aedes</i> mosquitoesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.