Article

Effects of metformin on cancers in experimental and clinical studies: Focusing on autophagy and AMPK/mTOR Signaling Pathways

2024-03-17

Abstract excerpt

Metformin (MET) is a preferred drug for the treatment of type 2 diabetes mellitus. Recent studies show that apart from its blood glucose-lowering effects, it also inhibits the development of various tumours, by inducing autophagy. Various studies have confirmed the inhibitory effects of MET on cancer cell lines’ propagation, migration, and invasion. The objective of the study was to comprehensively review the pote...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5573b3e-0d42-5c8b-8643-3df2c7a29906
DOI: 10.22541/au.171065529.99191979/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of metformin on cancers in experimental and clinical studies: Focusing on autophagy and AMPK/mTOR Signaling PathwaysDOI 10.22541/au.171065529.99191979/v1Read

Effect of metformin on the proliferation, apoptosis, invasion and autophagy of ovarian cancer cellsSemantic proximity Read

Metformin: an old drug with potential therapeutic function in antitumorSemantic proximity Read

Anti-tumor activity of metformin: from metabolic and epigenetic perspectivesSemantic proximity Read

Function and therapeutic potential of metformin in multiple diseasesSemantic proximity Read

Targeting mTOR as a Cancer Therapy: Recent Advances in Natural Bioactive Compounds and ImmunotherapySemantic proximity Read

Role of p53 Family Proteins in Metformin Anti-Cancer ActivitiesSemantic proximity Read

PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway?Semantic proximity Read

Metformin pathwaysSemantic proximity Read

K‑ras gene mutation as a predictor of cancer cell responsiveness to metformin.Semantic proximity Read

Metformin in aging and aging-related diseases: clinical applications and relevant mechanismsSemantic proximity Read

Autophagy: Mechanisms and Therapeutic Potential of Flavonoids in CancerSemantic proximity Read

p53 Modulation of Autophagy Signaling in Cancer Therapies: Perspectives Mechanism and Therapeutic TargetsSemantic proximity Read