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Humanized Klotho haplotypes cause widespread transcriptomic changes in mouse brain

2026-04-16

Abstract excerpt

Klotho KL is an aging factor that has been associated with Alzheimer’s Disease (AD) risk. Two common alleles circulate in human populations: the major allele FC and the minor allele VS, which is defined by two SNPs that cause two amino acid substitutions (F352V and C370S) in KL ’s second exon. To investigate the possibility that human KL variants influence brain aging and cognition, we developed a novel mouse m...

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Literature Corpus work
2a4a82f4-4a64-52fd-97de-d612d5aa2a3f
DOI
10.64898/2026.04.15.718745
Open publication

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Humanized Klotho haplotypes cause widespread transcriptomic changes in mouse brainDOI 10.64898/2026.04.15.718745
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