Article

KL-VS heterozygosity is associated with reduced tau accumulation and lower memory impairment in Alzheimer’s disease

2020-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Klotho-VS heterozygosity (KL-VS het ) is associated with reduced risk of Alzheimer’s disease (AD). However, whether KL-VS het is associated with lower levels of pathologic tau, i.e. the key AD pathology driving neurodegeneration and cognitive decline, is unknown. Here, we assessed the interaction between KL-VS het and levels of beta-amyloid, a key driver of tau pathology, on the levels of PET-ass...

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Literature Corpus work: 69ec325c-fe5c-5638-8c22-fe552bf9a8aa
DOI: 10.1101/2020.07.29.20164434

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