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Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden

22 Nov 2022

Abstract excerpt

Importance: Identification of proteins and genetic factors that reduce Alzheimer disease (AD) pathology is of importance when searching for novel AD treatments. Heterozygosity of the KL-VS haplotype has been associated with reduced amyloid and tau burden. Whether this association is mediated by the Klotho protein remains unclear. Objectives: To assess concentrations of Klotho in cerebrospinal fluid (CSF) and...

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PMID: 36413367
DOI: 10.1001/jamanetworkopen.2022.43232

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Related research

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Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau BurdenPMID 36413367Read ↗

Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4.Semantic proximity Read ↗

Leveraging large multi-center cohorts of Alzheimer Disease endophenotypes to understand the role of Klotho heterozygosity on disease riskSemantic proximity Read ↗

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.Semantic proximity Read ↗

Circulating Klotho Is Higher in Cerebrospinal Fluid than Serum and Elevated Among KLOTHO Heterozygotes in a Cohort with Risk for Alzheimer’s DiseaseSemantic proximity Read ↗

Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of Klotho heterozygosity on disease riskSemantic proximity Read ↗

KL-VS heterozygosity is associated with reduced tau accumulation and lower memory impairment in Alzheimer’s diseaseSemantic proximity Read ↗

KLOTHO heterozygosity attenuates APOE4 -related amyloid burden in preclinical ADSemantic proximity Read ↗

Age-Related Tau Burden and Cognitive Deficits Are Attenuated in KLOTHO KL-VS HeterozygotesSemantic proximity Read ↗

Longevity Klotho gene polymorphism and the risk of dementia in older men.Semantic proximity Read ↗

KLOTHO KL‐VS heterozygosity is associated with diminished age‐related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adultsSemantic proximity Read ↗

Systemic klotho is associated with KLOTHO variation and predicts intrinsic cortical connectivity in healthy human aging.Semantic proximity Read ↗

Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease.Semantic proximity Read ↗

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