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Article

Secreted and Transmembrane αKlotho Isoforms Have Different Spatio-Temporal Profiles in the Brain during Aging and Alzheimer's Disease Progression.

PloS one - 1 Jan 2015

Massó Anna, Sánchez Angela, Gimenez-Llort Lydia, Lizcano Jose Miguel, Cañete Manuel, García Belen, Torres-Lista Virginia, Puig Meritxell, Bosch Assumpció, Chillon Miguel

Abstract excerpt

The Klotho protein is a β-glucuronidase, and its overexpression is associated with life extension. Its mechanism of action is not fully understood, although it has been recently reported that αKlotho improves synaptic and cognitive functions, and it may also influence a variety of structures and functions during CNS maturation and aging. The αKlotho gene has two transcripts, one encoding a transmembrane isoform...

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Source

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Identifiers

PMID: 26599613
DOI: 10.1371/journal.pone.0143623
PMCID: PMC4658185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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