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Exposure accumulation drives age-dependent disease architectures and polygenic risk scores

2025-12-08

Abstract excerpt

<title>Abstract</title> <p> Our understanding of the dependence of the genetic and environmental architecture of common diseases on age is incomplete. Here, we use longitudinal data to separate age-dependent genetic and environmental variance across complex traits and diseases. When applying our approach to 16 UK Biobank quantitative traits (average N=180K), we found environmental variance accumulates with age,...

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Literature Corpus work
ebfaa1e4-6a7e-5245-b51c-baeafe26f13f
DOI
10.21203/rs.3.rs-8123157/v1
Open publication

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Exposure accumulation drives age-dependent disease architectures and polygenic risk scoresDOI 10.21203/rs.3.rs-8123157/v1
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