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Article

CRISPRi Screen Identifies a Novel Growth Suppressor lncRNA, <i>INSTAR</i> , in Human Monocytes

2025-10-31

Abstract excerpt

Acute myeloid leukemia (AML) is a heterogeneous disease that arises from dysregulated myeloid proliferation. We performed a high-throughput CRISPR interference (CRISPRi) screen in the THP-1 monocytic cancer cell line to identify long noncoding RNAs (lncRNAs) that play a role in contributing to cell proliferation. Our screen identified INSTAR (Intergenic Nuclear Suppressor lncRNA Targeting Adjacent Regulator SFMB...

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Literature Corpus work
2a37418d-ca10-5522-a586-791ec357210e
DOI
10.1101/2025.10.30.685589
Open publication

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CRISPRi Screen Identifies a Novel Growth Suppressor lncRNA, <i>INSTAR</i> , in Human MonocytesDOI 10.1101/2025.10.30.685589
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