Article

Vascular dysfunction in Huntington’s disease is located at the blood-CSF barrier and is rescued by sphingosine-1-phosphate receptor agonist

2025-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Brain vascular barriers are dysfunctional in many neurological disorders, including Huntington’s disease (HD), but which vessels are affected and how remains unclear. Using in vivo two-photon microscopy in R6/2 HD-model mice, we reveal a striking divergence in barrier dysfunction. Surface vessels of the blood-cerebrospinal fluid barrier (BCSFB) drive pathology by paracellular leakage, while the...

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Literature Corpus work: e4de6f9e-0d02-5c2a-969e-4f0e67baa21d
DOI: 10.1101/2025.04.30.650996

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