Article

Hemodynamic Signals Reshape Biological Inference in Widefield Calcium Imaging

2026-07-09

Abstract excerpt

Widefield calcium imaging is widely used to study cortex-wide neural dynamics, yet fluorescence signals are strongly influenced by hemodynamic fluctuations arising from blood volume and oxygenation changes. Although hemodynamic correction is frequently applied, it remains unclear whether vascular contributions represent a modest preprocessing concern or systematically bias biological interpretations of cortical ac...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f0094432-c13a-57d0-93a4-7b790b38dc8a
DOI: 10.64898/2026.07.03.736453

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hemodynamic Signals Reshape Biological Inference in Widefield Calcium ImagingDOI 10.64898/2026.07.03.736453Read

Cerebral cortical functional hyperconnectivity in a mouse model of spinocerebellar ataxia type 8 (SCA8)Semantic proximity Read

An open source statistical and data processing toolbox for wide-field optical imaging in miceSemantic proximity Read

Time-Resolved Neuronal Network Dynamics Distinguish Pathological States in Organoid ModelsSemantic proximity Read

Functional network properties derived from wide-field calcium imaging differ with wakefulness and across cell typeSemantic proximity Read

Brain anatomy and molecular signaling predict neurophysiological dynamics across the lifespanSemantic proximity Read

An engine for systematic discovery of cause-effect relationships between brain structure and functionSemantic proximity Read

Neuronal and physiological correlation to hemodynamic resting-state fluctuations in health and disease.Semantic proximity Read

Assessing molecular, cellular and transcriptomic bases of laminar perfusion and cytoarchitecture coupling in the human cortexSemantic proximity Read

Near-lifespan longitudinal tracking of brain microvascular morphology, topology, and flow in male miceSemantic proximity Read

Glioblastoma disrupts cortical network activity at multiple spatial and temporal scalesSemantic proximity Read

The landscape of functional brain network impairments in late-onset GM2 gangliosidosisSemantic proximity Read

BrainSpace: a toolbox for the analysis of macroscale gradients in neuroimaging and connectomics datasetsSemantic proximity Read