Article

Matrix Stiffness Modulates Metabolic Interaction Between Human Stromal and Breast Cancer Cells to Stimulate Epithelial Motility

2021-02-09

Abstract excerpt

<title>Abstract</title> <p><bold>Background. </bold>Breast tumors belong to the type of desmoplastic lesion in which a stiffer tissue structure is a determinant of breast cancer progression and constitutes a risk factor for breast cancer development. It has been proposed that cancer-associated stromal cells (responsible for this fibrotic phenomenon) are able to metabolize glucose via lactate production, which sup...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2a015842-682c-5085-b374-076065e471cf
DOI: 10.21203/rs.3.rs-186889/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Matrix Stiffness Modulates Metabolic Interaction Between Human Stromal and Breast Cancer Cells to Stimulate Epithelial MotilityDOI 10.21203/rs.3.rs-186889/v1Read

Dynamic links between mechanical forces and metabolism shape the tumor milieu.Semantic proximity Read

Breast cancer cells mechanosensing in engineered matrices: Correlation with aggressive phenotype.Semantic proximity Read

Distinct phenotypes of cancer cells on tissue matrix gel.Semantic proximity Read

Small extracellular vesicles promote stiffness-mediated metastasisSemantic proximity Read

Instant fluorescence lifetime imaging microscopy reveals mechano-metabolic reprogramming of stromal cells in breast cancer peritumoral microenvironmentsSemantic proximity Read

Gravitational forces and matrix stiffness modulate the invasiveness of breast cancer cells in bioprinted spheroidsSemantic proximity Read

Biophysics of Tumor Microenvironment and Cancer Metastasis - A Mini ReviewSemantic proximity Read

The 3D Collagen Network as a Determinant of Tumor Progression and Drug Delivery Efficiency in Breast AdenocarcinomaSemantic proximity Read

The Dynamic Interaction between Extracellular Matrix Remodeling and Breast Tumor ProgressionSemantic proximity Read

Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptationsSemantic proximity Read

Mechanical Fingerprints in Breast Cancer Research: A Multimodal Experimental ApproachSemantic proximity Read

A Human Organotypic Microfluidic Tumor Model Permits Investigation of the Interplay between Patient-Derived Fibroblasts and Breast Cancer CellsSemantic proximity Read