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Organotypic microfluidic breast cancer model reveals starvation-induced spatial-temporal metabolic adaptations

26 Oct 2018

Abstract excerpt

BACKGROUND: Ductal carcinoma in situ (DCIS) is the earliest stage of breast cancer. During DCIS, tumor cells remain inside the mammary duct, growing under a microenvironment characterized by hypoxia, nutrient starvation, and waste product accumulation; this harsh microenvironment promotes genomic instability and eventually cell invasion. However, there is a lack of biomarkers to predict what patients will...

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PMID: 30482722
DOI: 10.1016/j.ebiom.2018.10.046

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