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Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms

2 Dec 2014

Abstract excerpt

Patients with myeloproliferative neoplasms (MPNs) are at significant, cumulative risk of leukemic transformation to acute myeloid leukemia (AML), which is associated with adverse clinical outcome and resistance to standard AML therapies. We performed genomic profiling of post-MPN AML samples; these studies demonstrate somatic tumor protein 53 (TP53) mutations are common in JAK2V617F-mutant, post-MPN AML but not...

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PMID: 25516983
DOI: 10.1073/pnas.1407792111

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