Article
BMP2/SMAD pathway activation in JAK2/p53-mutant megakaryocyte/erythroid progenitors promotes leukemic transformation.
Blood - 23 Jun 2022
Li Bing, An Wenbin, Wang Hua, Baslan Timour, Mowla Shoron, Krishnan Aishwarya, Xiao Wenbin, Koche Richard P, Liu Ying, Cai Sheng F, Xiao Zhijian, Derkach Andriy, Iacobucci Ilaria, Mullighan Charles G, Helin Kristian, Lowe Scott W, Levine Ross L, Rampal Raajit K
Abstract excerpt
Leukemic transformation (LT) of myeloproliferative neoplasm (MPN) has a dismal prognosis and is largely fatal. Mutational inactivation of TP53 is the most common somatic event in LT; however, the mechanisms by which TP53 mutations promote LT remain unresolved. Using an allelic series of mouse models of Jak2/Trp53 mutant MPN, we identify that only biallelic inactivation of Trp53 results in LT (to a pure...
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