Article

Cockayne syndrome mice reflect human kidney disease and are defective in de novo NAD biosynthesis

2024-10-10

Abstract excerpt

<title>Abstract</title> <p>Cockayne Syndrome (CS) is a premature aging disorder caused by mutations in the CSA and CSB genes involved in DNA metabolism and other cellular processes. CS patients display many features including premature aging, neurodegeneration, and kidney abnormalities. Nicotinamide dinucleotide (NAD<sup>+</sup>) deprivation has been oberserved in CS patient-derived cells. NAD<sup>+</sup> has ess...

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Literature Corpus work: 29f17f8e-cada-564a-9665-da25c42b503f
DOI: 10.21203/rs.3.rs-4882865/v1

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