Article

STING and VDAC inhibitors attenuate inflammation and ineffective erythropoiesis caused by an altered metabolome in the <i>Nan</i> (EKLF/E339D) mouse model of neonatal anemia

2025-12-12

Abstract excerpt

<h4>SUMMARY</h4> Erythroid Krüppel-like factor (EKLF/KLF1) is an essential transcriptional regulator of all aspects of erythropoiesis. The mouse neonatal anemia ( Nan ) mutation is driven by a semi-dominant mutation in one allele of the EKLF second Zn-finger at position E339D. RNA-seq analysis of Nan/+ erythroid cells showed that expression of numerous enzymes associated with metabolic pathways are changed as a...

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Literature Corpus work: 1840b9f5-0038-5cb5-b920-21093586cb1d
DOI: 10.64898/2025.12.11.693792

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STING and VDAC inhibitors attenuate inflammation and ineffective erythropoiesis caused by an altered metabolome in the <i>Nan</i> (EKLF/E339D) mouse model of neonatal anemiaDOI 10.64898/2025.12.11.693792Read

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