Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene.

doi:10.1038/ncomms14581

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Article

Genomic characterisation of Eμ-Myc mouse lymphomas identifies Bcor as a Myc co-operative tumour-suppressor gene.

Nature communications - 6 Mar 2017

Lefebure Marcus, Tothill Richard W, Kruse Elizabeth, Hawkins Edwin D, Shortt Jake, Matthews Geoffrey M, Gregory Gareth P, Martin Benjamin P, Kelly Madison J, Todorovski Izabela, Doyle Maria A, Lupat Richard, Li Jason, Schroeder Jan, Wall Meaghan, Craig Stuart, Poortinga Gretchen, Cameron Don, Bywater Megan, Kats Lev, Gearhart Micah D, Bardwell Vivian J, Dickins Ross A, Hannan Ross D, Papenfuss Anthony T, Johnstone Ricky W

Abstract excerpt

The Eμ-Myc mouse is an extensively used model of MYC driven malignancy; however to date there has only been partial characterization of MYC co-operative mutations leading to spontaneous lymphomagenesis. Here we sequence spontaneously arising Eμ-Myc lymphomas to define transgene architecture, somatic mutations, and structural alterations. We identify frequent disruptive mutations in the PRC1-like component and...

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Identifiers

PMID: 28262675
DOI: 10.1038/ncomms14581
PMCID: PMC5343491

Genes

MYC
BCL6
PRC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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