Article
Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma.
Blood - 28 Feb 2013
Green Michael R, Gentles Andrew J, Nair Ramesh V, Irish Jonathan M, Kihira Shingo, Liu Chih Long, Kela Itai, Hopmans Erik S, Myklebust June H, Ji Hanlee, Plevritis Sylvia K, Levy Ronald, Alizadeh Ash A
Abstract excerpt
Follicular lymphoma (FL) is currently incurable using conventional chemotherapy or immunotherapy regimes, compelling new strategies. Advances in high-throughput sequencing technologies that can reveal oncogenic pathways have stimulated interest in tailoring therapies toward actionable somatic mutations. However, for mutation-directed therapies to be most effective, the mutations must be uniformly present in...
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