Article

The genetics and kinetics of BCL2 driven lymphoid malignancies

2015-01-01

Abstract excerpt

Introduction: Non-Hodgkin Lymphoma (NHL) is rising in incidence. Treatment of this genetically heterogeneous disease has toxic side effects and significant numbers of relapsers / non-responders. BCL2, an anti-apoptotic protein, is commonly overexpressed in NHL as a result of the t(14;18) translocation. A number of BCL2 inhibitors have shown success in clinical trials but variable efficacy has meant that none have...

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Literature Corpus work: 6bbaf751-7647-5615-be12-8211a437ff28
DOI: 10.25560/45406

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