Article
Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates.
Nature communications - 9 Jul 2018
Webster Philip, Dawes Joanna C, Dewchand Hamlata, Takacs Katalin, Iadarola Barbara, Bolt Bruce J, Caceres Juan J, Kaczor Jakub, Dharmalingam Gopuraja, Dore Marian, Game Laurence, Adejumo Thomas, Elliott James, Naresh Kikkeri, Karimi Mohammad, Rekopoulou Katerina, Tan Ge, Paccanaro Alberto, Uren Anthony G
Abstract excerpt
Determining whether recurrent but rare cancer mutations are bona fide driver mutations remains a bottleneck in cancer research. Here we present the most comprehensive analysis of murine leukemia virus-driven lymphomagenesis produced to date, sequencing 700,000 mutations from >500 malignancies collected at time points throughout tumor development. This scale of data allows novel statistical approaches for...
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