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Article

Pulsed electron spin resonance resolves the coordination site of Cu²(+) ions in α1-glycine receptor.

Biophysical journal - 20 Oct 2010

Ruthstein Sharon, Stone Katherine M, Cunningham Timothy F, Ji Ming, Cascio Michael, Saxena Sunil

Abstract excerpt

Herein, we identify the coordination environment of Cu²(+) in the human α1-glycine receptor (GlyR). GlyRs are members of the pentameric ligand-gated ion channel superfamily (pLGIC) that mediate fast signaling at synapses. Metal ions like Zn²(+) and Cu²(+) significantly modulate the activity of pLGICs, and metal ion coordination is essential for proper physiological postsynaptic inhibition by GlyR in vivo. Zn²(+)...

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Identifiers

PMID: 20959090
DOI: 10.1016/j.bpj.2010.08.050
PMCID: PMC2955494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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