Article
Loop F of the GABAA receptor alpha subunit governs GABA potency.
Neuropharmacology - 1 Jan 2018
Pálvölgyi Adrienn, Móricz Krisztina, Pataki Ágnes, Mihalik Balázs, Gigler Gábor, Megyeri Katalin, Udvari Szabolcs, Gacsályi István, Antoni Ferenc A
Abstract excerpt
Gamma-amino butyric acid (GABA) is an abundant neurotransmitter in the CNS. GABAergic interneurons orchestrate pyramidal neurons in the cerebral cortex, and thus control learning and memory. Ionotropic receptors for GABA (GABAAR) are heteropentameric complexes of α, β and γ integral membrane-protein subunits forming Cl- -channels operated by GABA, which are vital for brain function and are important drug targets....
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