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Article

Interaction between GABAA receptor α1 and β2 subunits at the N-terminal peripheral regions is crucial for receptor binding and gating.

Biochemical pharmacology - 1 Jan 2021

Terejko Katarzyna, Michałowski Michał A, Dominik Anna, Andrzejczak Anna, Mozrzymas Jerzy W

Abstract excerpt

Pentameric ligand gated ion channels (pLGICs) are crucial in electrochemical signaling but exact molecular mechanisms of their activation remain elusive. So far, major effort focused on the top-down molecular pathway between the ligand binding site and the channel gate. However, recent studies revealed that pLGIC activation is associated with coordinated subunit twisting in the membrane plane. This suggests a key...

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PMID: 33189674
DOI: 10.1016/j.bcp.2020.114338

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