Article

Early loss of Scribble affects cortical development and interhemispheric connectivity resulting in psychomotor dysregulation

2019-09-23

Abstract excerpt

Neurodevelopmental disorders arise from combined defects in processes including cell proliferation, differentiation, migration and commissure formation. The evolutionarily conserved tumor-suppressor protein Scribble (Scrib) serves as a nexus to transduce signals for the establishment of apicobasal and planar cell polarity during these processes. Human SCRIB gene mutations are associated with neural tube defects a...

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Literature Corpus work: 29a0b7fd-3f81-5ea7-9053-f64b076a4ccf
DOI: 10.1101/780130

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