Article
The planar polarity protein Scribble1 is essential for neuronal plasticity and brain function.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Jul 2010
Moreau Maïté M, Piguel Nicolas, Papouin Thomas, Koehl Muriel, Durand Christelle M, Rubio Maria E, Loll François, Richard Elodie M, Mazzocco Claire, Racca Claudia, Oliet Stéphane H R, Abrous D Nora, Montcouquiol Mireille, Sans Nathalie
Abstract excerpt
Scribble (Scrib) is a key regulator of apicobasal polarity, presynaptic architecture, and short-term synaptic plasticity in Drosophila. In mammals, its homolog Scrib1 has been implicated in cancer, neural tube closure, and planar cell polarity (PCP), but its specific role in the developing and adult nervous system is unclear. Here, we used the circletail mutant, a mouse model for PCP defects, to show that Scrib1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.