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Article

Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse.

Human molecular genetics - 15 Jan 2003

Murdoch Jennifer N, Henderson Deborah J, Doudney Kit, Gaston-Massuet Carles, Phillips Helen M, Paternotte Caroline, Arkell Ruth, Stanier Philip, Copp Andrew J

Abstract excerpt

Circletail is one of only two mouse mutants that exhibit the most severe form of neural tube defect (NTD), termed craniorachischisis. In this disorder, almost the entire brain and spinal cord is affected, owing to a failure to initiate neural tube closure. Craniorachischisis is a significant cause of lethality in humans, yet the molecular mechanisms involved remain poorly understood. Here, we report the...

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PMID: 12499390
DOI: 10.1093/hmg/ddg014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse.PMID 12499390Read ↗

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