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Article

Scribble Controls Social Motivation Behavior through the Regulation of the ERK/Mnk1 Pathway.

Cells - 10 May 2022

Moreau Maïté M, Pietropaolo Susanna, Ezan Jérôme, Robert Benjamin J A, Miraux Sylvain, Maître Marlène, Cho Yoon, Crusio Wim E, Montcouquiol Mireille, Sans Nathalie

Abstract excerpt

Social behavior is a basic domain affected by several neurodevelopmental disorders, including ASD and a heterogeneous set of neuropsychiatric disorders. The SCRIB gene that codes for the polarity protein SCRIBBLE has been identified as a risk gene for spina bifida, the most common type of neural tube defect, found at high frequencies in autistic patients, as well as other congenital anomalies. The deletions and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35626639
DOI: 10.3390/cells11101601
PMCID: PMC9139383

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