Article

Alzheimer’s disease risk factor APOE4 exerts dimorphic effects on female bone

2025-10-16

Abstract excerpt

<h4>ABSTRACT</h4> Individuals diagnosed with Alzheimer’s disease (AD) are at an increased risk of bone fractures. Conversely, a diagnosis of osteoporosis in women is the earliest known predictor for AD. However, mechanisms responsible for the coupled decline in cognitive and skeletal health remain unclear. Proteomic analysis of cortical bone from aged mice revealed neurological disease-associated proteins that ar...

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Literature Corpus work: 299ca978-71b3-5451-ad11-cf6e25d75d8b
DOI: 10.1101/2025.10.16.682922

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