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Article

Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging

23 May 2025

Abstract excerpt

Abstract Age-related osteoporosis poses a significant challenge in musculoskeletal health; a condition characterized by reduced bone density and increased fracture susceptibility in older individuals necessitates a better understanding of underlying molecular and cellular mechanisms. Emerging evidence suggests that osteocytes are the pivotal orchestrators of bone remodeling and represent novel therapeutic targets...

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PMID: 40410139
DOI: 10.1038/s41413-025-00428-x

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