Article

TAp73 regulates mitochondrial dynamics and multiciliated cell homeostasis through an OPA1 axis

2023-03-24

Abstract excerpt

<h4>ABSTRACT</h4> Dysregulated mitochondrial fusion and fission has been implicated in the pathogenesis of numerous diseases. We have identified a novel function of the p53 family protein TAp73 in regulating mitochondrial dynamics. TAp73 regulates the expression of Optic atrophy 1, a protein responsible for controlling mitochondrial fusion, cristae biogenesis and electron transport chain function. Disruption of t...

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Identifiers and source

Literature Corpus work: 298ee69b-b47e-5275-993a-fc3a9ba4b6b8
DOI: 10.1101/2023.03.23.533672

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